Clinical aspect, pathogenesis and therapy options of alopecia induced by hormonal therapy for breast cancer

    Alfredo Rossi, Gemma Caro, Francesca Magri, Maria Caterina Fortuna, Marta Carlesimo
    TLDR Breast cancer hormone therapy can cause hair loss, which can be treated with daily applications of specific topical solutions like minoxidil and hydrocortisone butyrate.
    Adjuvant hormonal therapy for hormone-receptor-positive breast cancer often results in hair loss similar to female androgenic alopecia, known as oncotherapy-induced alopecia. This hair loss, while not severe, significantly affects patients' quality of life. It is caused by the therapy's inhibition of estrogenic activity, which increases dehydrotestosterone (DHT) levels around hair follicles, shortening the hair growth phase and altering hair texture. The authors recommend against using topical hormones to treat this hair loss due to potential oncogenic effects. Instead, they suggest a treatment approach using topical formulations containing minoxidil 2%, cetirizine 0.5%, and hydrocortisone butyrate in alcohol, applied daily during the hormonal therapy. For more severe cases, or if previous female androgenic alopecia was present, a formulation of minoxidil 5% and hydrocortisone butyrate 0.1% is recommended.
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