Clascoterone in the Treatment of Acne Vulgaris: A Narrative Review

    August 2026 in “ Pharmaceuticals ”
    Sara Shefa, Jagoda Szwach, Anna Karwowska … Magdalena Łyko
    Studysummary This review summarizes existing evidence about clascoterone cream, which significantly reduces acne lesions with a favorable safety profile, but reports no new clinical results and suggests further research for other potential applications.
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    Research cited in this study 9

    1. Real-World Experience of Clascoterone Cream 1% in Acne Management: Case Series and Canadian Experience Clinical Cosmetic and Investigational Dermatology · 2025
    2. Hormonal Therapies for Acne: A Comprehensive Update for Dermatologists Dermatology and Therapy · 2025
    3. Guidelines of Care for the Management of Acne Vulgaris Journal of the American Academy of Dermatology · 2024
    4. Use of Topical Clascoterone for the Treatment of Hidradenitis Suppurativa JAAD Case Reports · 2023
    5. A Phase 1 Study to Investigate the Effects of Cortexolone 17α-Propionate, Also Known as Clascoterone, on the QT Interval Using the Meal Effect to Demonstrate ECG Assay Sensitivity Clinical Pharmacology in Drug Development · 2021
    6. Clascoterone: First Approval Drugs · 2020
    7. Clascoterone as a Novel Treatment for Androgenetic Alopecia Clinical and Experimental Dermatology · 2020
    8. The Role of Androgen and Androgen Receptor in Skin-Related Disorders Archives of Dermatological Research · 2012
    9. Acne American journal of clinical dermatology · 2002