Carnosic Acid in Topical Rosemary Extract Enhances Skin Repair via TRPA1 Activation

    October 2025 in “ JCI Insight ”
    Emmanuel Rapp, Jiayun Pang, Borna Saeednia … Thomas Leung
    Studysummary In a mouse model, this study found that an ethanol-based rosemary extract speeds up wound healing and reduces scarring by activating the TRPA1 nociceptor in sensory neurons, with carnosic acid identified as a key component.
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    Research cited in this study 6

    1. Granulocyte Colony Stimulating Factor Promotes Scarless Tissue Regeneration Cell Reports · 2024
    2. Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions Advances in wound care · 2016
    3. Wound Healing and Skin Regeneration Cold Spring Harbor Perspectives in Medicine · 2015
    4. Advances in Skin Grafting and Treatment of Cutaneous Wounds Science · 2014
    5. Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys) Nature · 2012
    6. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007