Genetic Variant of the Canine FGF5 Gene for the Hair Length Trait in the Akita: Utility for Hair Coat Variations and Welfare in Conservation Breeding

    August 2025 in “ Genes ”
    Shinichiro Maki, Md Shafiqul Islam, Norio Kansaku … Osamu Yamato
    Studysummary This study identified the FGF5:c.578C>T variant as linked to long hair in Akitas in Japan and suggests that genetic testing could help improve their breeding practices and welfare.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 8

    1. A Homozygous Missense Mutation in the Fibroblast Growth Factor 5 Gene Is Associated with the Long-Hair Trait in Angora Rabbits BMC genomics · 2023
    2. Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12) International Journal of Molecular Sciences · 2022
    3. Effect of Cysteine-Free Human Fibroblast Growth Factor-5s Mutant (FGF5sC93S) on Hair Growth Dermatologic Therapy · 2020
    4. Hair of the Dog: Identification of a Cis-Regulatory Module Predicted to Influence Canine Coat Composition Genes · 2019
    5. FGF5 Is a Crucial Regulator of Hair Length in Humans Proceedings of the National Academy of Sciences of the United States of America · 2014
    6. Four Independent Mutations in the Feline Fibroblast Growth Factor 5 Gene Determine the Long-Haired Phenotype in Domestic Cats Journal of Heredity · 2007
    7. Hyperadrenocorticism Associated With Sex Steroid Excess Clinical techniques in small animal practice · 2007
    8. The Long And The Short Of It: Evidence That FGF5 Is A Major Determinant Of Canine Hair-Itability Animal genetics · 2006