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GlossaryFibroblast Growth Factor 5 (FGF5 gene)

protein that inhibits hair growth by signaling phase transition

Fibroblast Growth Factor 5 (FGF5) is a protein that plays a crucial role in regulating the hair growth cycle. Specifically, it acts to inhibit hair growth by signaling the transition from the growth phase (anagen) to the regression phase (catagen), which can lead to shorter hair growth periods and potentially contribute to conditions like alopecia.

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research Genetic Variant of the Canine FGF5 Gene for the Hair Length Trait in the Akita: Utility for Hair Coat Variations and Welfare in Conservation Breeding

August 2025 in “Genes”

The FGF5 gene variant causes long hair in Akitas, and genetic testing is advised to manage coat length and welfare.

research Pilot Study: Genetic Distribution of AR, FGF5, SULT1A1, and CYP3A5 Polymorphisms in Male Mexican Population with Androgenetic Alopecia

January 2022 in “PubMed”

Certain genetic variations are linked to hair loss in Mexican men.

research Bioinformatics Analysis of Evolutionary Characteristics and Biochemical Structure of FGF5 Gene in Sheep

23 citations , March 2019 in “Gene”

Editing the FGF5 gene in sheep increases wool length, confirming its role in hair growth.

research Molecular Cloning, Characterization, and Expression of Sheep FGF5 Gene

11 citations , October 2014 in “Gene”

Researchers identified a new variant of the FGF5 gene in sheep that affects hair length.

research Effect of Melatonin on Genes Including FGF5 Related to Hair Growth in Cashmere Goat Skin

June 2012

Melatonin increased the activity of a hair growth gene in Cashmere goats.

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community Mystery compound found to be safe and effective at treating hair loss. Details in comments.

in Technology 6 upvotes 7 years ago

A compound called MTP3 from the Monoterpene family was found to be safe and highly effective at treating hair loss by inhibiting the FGF5 gene, but its identity is undisclosed for commercial reasons. No specific treatments like Minoxidil, finasteride, or RU58841 were discussed.

community DIY treatment... Shedding completely stopped after 1.5 yrs

in Treatment 250 upvotes 4 years ago

Vitamin C mixed with shampoo stopped shedding and promoted hair regrowth after 1.5 years. Both the person and their wife experienced significant hair loss reduction with this method.

community Sanguisorba Officinalis Root Extract, and other FGF-5 inhibitors?

in Question 4 upvotes 9 years ago

The conversation discusses the potential of Sanguisorba Officinalis Root Extract as a treatment for hair loss by inhibiting FGF-5. The user also mentions the product évolis, which is based on this extract but is only available in the US and Australia.