Coexistence of Bullous Pemphigoid, Intrahepatic Cholangiocarcinoma, and Alopecia Areata: A Case Report of Multifactorial Autoimmunity in a Surgical Context

    August 2025 in “ Frontiers in Immunology ”
    Shanlin Li, Ying Wang, Dingquan Yang
    Studysummary This case report is the first to document the coexistence of bullous pemphigoid, malignant tumors, and alopecia areata in a patient, highlighting the complete resolution of skin lesions with dupilumab and spontaneous hair regrowth without disease-specific treatment.
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    Research cited in this study 11

    1. Understanding the Intricate Pathophysiology of Psoriasis and Related Skin Disorders International Journal of Molecular Sciences · 2025
    2. Dupilumab and Alopecia Areata: A Possible Combined or Disturbance Therapy? A Review of the Literature Dermatology Practical & Conceptual · 2024
    3. Innovative Strategies for the Discovery of New Drugs Against Alopecia Areata: Taking Aim at the Immune System Expert Opinion on Drug Discovery · 2024
    4. Hair Regrowth in Alopecia Areata and Re-Pigmentation in Vitiligo in Response to Treatment: Commonalities and Differences Journal of the European Academy of Dermatology and Venereology · 2024
    5. Deciphering the Complex Immunopathogenesis of Alopecia Areata International Journal of Molecular Sciences · 2024
    6. Dupilumab Therapy for Alopecia Areata: A Case Series and Review of the Literature Journal of Dermatological Treatment · 2024
    7. Comorbid Conditions Associated With Alopecia Areata: A Systematic Review and Meta-Analysis American Journal of Clinical Dermatology · 2023
    8. Granzyme B in Autoimmune Skin Disease Biomolecules · 2023
    9. Clinical Manifestations of Alopecia in Autoimmune Blistering Diseases: A Cross-Sectional Study JAAD international · 2022
    10. Linagliptin-Associated Alopecia and Bullous Pemphigoid European Journal of Case Reports in Internal Medicine · 2019
    11. Comorbidities in Alopecia Areata: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2018