Brown adipose tissue in the form of innovative approach for polycystic ovary syndrome treatmentstill long time to reach clinical arena: a narrative review

    August 2023 in “MOJ women's health
    TLDR Brown Adipose Tissue (BAT) could potentially treat Polycystic Ovary Syndrome (PCOS) by controlling energy balance and lipid homeostasis, but more human research is needed.
    The narrative review discusses the potential of Brown Adipose Tissue (BAT) in treating Polycystic Ovary Syndrome (PCOS), a disorder affecting 20-25% of women of reproductive age. The review analyzed 100 articles and found that BAT's endocrine action impacts energy balance and lipid homeostasis, which can control PCOS properties. Increasing BAT mass/activity can be effective in treating PCOS through cold stimulation, BAT transplantation, and activation with substances like rutin. BAT can also oxidize glucose and triglycerides from the blood, helping maintain metabolic homeostasis. However, most studies have been conducted in animals, and more research is needed to validate these findings in humans.
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