Stabilization of Beta-Catenin Promotes Melanocyte Specification at the Expense of the Schwann Cell Lineage

    June 2020 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Sophie Colombo, Valérie Petit, Roselyne Y Wagner, Delphine Champeval, Ichiro Yajima, Franck Gesbert, Irwin Davidson, Véronique Delmas, Lionel Larue
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    TLDR Activating β-catenin increases melanocytes and decreases Schwann cells.
    The study investigated the role of β-catenin in melanocyte development by generating mice with a constitutively active form of β-catenin in tyrosinase-expressing cells. It was found that β-catenin activation did not affect truncal melanoblasts but caused hyperpigmentation in the paws. When activated during specific developmental stages (E8.5-E11.5), β-catenin favored melanoblast specification over Schwann cells in the limbs by inducing MITF and repressing FoxD3. This indicated that β-catenin overexpression promoted the melanocyte lineage at the expense of Schwann cells.
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