TLDR Activating β-catenin increases melanocytes and decreases Schwann cells.
The study investigated the role of β-catenin in melanocyte development by generating mice with a constitutively active form of β-catenin in tyrosinase-expressing cells. It was found that β-catenin activation did not affect truncal melanoblasts but caused hyperpigmentation in the paws. When activated during specific developmental stages (E8.5-E11.5), β-catenin favored melanoblast specification over Schwann cells in the limbs by inducing MITF and repressing FoxD3. This indicated that β-catenin overexpression promoted the melanocyte lineage at the expense of Schwann cells.
19 citations,
April 2016 in “Experimental Dermatology” Melanoblasts migrate to the skin using various pathways, and understanding this process could help with skin disease research.
[object Object]
37 citations,
November 2017 in “Medical Sciences” Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.
April 2024 in “Journal of translational medicine” Melanocytes are important for normal body functions and have potential uses in regenerative medicine and disease treatment.
33 citations,
December 2015 in “International Journal of Molecular Sciences” Melanocyte stem cells are crucial for skin pigmentation and have potential in disease modeling and regenerative medicine.
[object Object] 
1 citations,
June 2023 in “Cells” Exosomes could be a promising way to help repair skin and treat skin disorders.
10 citations,
September 2021 in “International Journal of Nanomedicine” Tiny particles called extracellular vesicles show promise for treating skin conditions and promoting hair growth.
