Animal models of androgen-dependent disorders of the pilosebaceous apparatus
July 1989
in “Archives of dermatological research”
TLDR Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.
In 1989, researchers studied the AGA mouse as a model for male-pattern baldness, finding that testosterone (T) injections caused hair loss by affecting the hair growth cycle, with dihydrotestosterone (DHT) being more potent. Topical cyproterone acetate at 5% concentration and a diet with 0.01% minoxidil were effective in delaying or inhibiting T-induced hair loss in these mice. The study demonstrated that the AGA mouse is a suitable model for testing potential baldness treatments due to its similarity to human AGA, with topical minoxidil at 5% showing a 60% inhibition of hair loss after 12 weeks (p < 0.03). The study also noted that the incidence of spontaneous alopecia in AGA mice is low without T treatment, that alopecia severity is age-dependent, and that other hypertrichosis-inducing drugs like diazoxide can inhibit T-induced hair loss, while some others are ineffective.
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