146 citations
,
January 2004 in “Hormones” This review explores the complex endocrine functions of human skin and its role as a peripheral endocrine organ, but reports no new clinical results.
289 citations
,
May 2003 in “Journal of Investigative Dermatology” This study demonstrates that human skin is capable of steroid hormone synthesis, but its role in androgenic skin disorders like acne and alopecia is yet to be clarified.
117 citations
,
January 2003 in “Dermatology” This review discusses various treatments for moderate-to-severe acne, highlighting antibiotics, oral isotretinoin, and hormonal therapies, with a focus on resistance and emerging treatment options but reports no new clinical results.
233 citations
,
November 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” This review explores androgen metabolism in the skin, highlighting enzyme localization and potential implications for treating androgen-dependent skin conditions, but it reports no new clinical results.
13 citations
,
October 2002 in “Journal of Biochemical and Biophysical Methods” This study found that men with androgenic alopecia had significantly higher levels of certain urinary steroid metabolites, suggesting increased 5 alpha-reductase activity and possible mild hyperadrenal activity.
9 citations
,
September 2002 in “The Journal of clinical investigation/The journal of clinical investigation” This study found that reducing testosterone levels in male mice accelerates wound healing and decreases inflammation, suggesting a potential therapeutic target for improving wound repair in elderly males.
61 citations
,
December 2001 in “Journal of Investigative Dermatology” This study found that steroid sulfatase in the dermal papilla of hair follicles metabolizes dehydroepiandrosterone sulfate to support the development of androgenetic alopecia, suggesting potential for steroid sulfatase inhibitors as treatments.
196 citations
,
May 2001 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that SZ95 sebocytes and HaCaT keratinocytes exhibit distinct enzyme expressions and activities, implicating their different roles in androgen metabolism and homeostasis in vitro.
82 citations
,
January 2000 in “Hormone Research in Paediatrics” This study describes the enzymatic processes through which DHEA is converted to active sex steroids in human skin, highlighting an androgenic effect on sebaceous glands and estrogenic effects in the vagina.
30 citations
,
December 1999 in “Journal of Investigative Dermatology Symposium Proceedings” This study found that in vitro treatments with 5alpha-reductase inhibitors and androgen receptor antagonists strongly stimulate VEGF expression in dermal papilla cells.
1113 citations
,
August 1999 in “The New England Journal of Medicine” This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hair follicle research.
581 citations
,
October 1998 in “Journal of The American Academy of Dermatology” In male pattern hair loss, this study found that finasteride 1 mg daily significantly slowed hair loss and increased hair growth over two years compared to placebo.
45 citations
,
September 1998 in “Journal of Investigative Dermatology” This study found that sebaceous glands predominantly exhibit oxidative activity of the type 2 17β-hydroxysteroid dehydrogenase isozyme, which is not inhibited by 13-cis retinoic acid.
186 citations
,
July 1998 in “Journal of Cutaneous Medicine and Surgery” This study found that shorter CAG-repeat lengths in the androgen receptor may be associated with the development of androgen-mediated skin disorders like androgenetic alopecia, acne, and hirsutism in both men and women.
83 citations
,
January 1998 in “Journal of Investigative Dermatology” In this study using human cell cultures, type 1 5α-reductase was found to vary in both protein heterogeneity and expression levels across different types of skin cells.