Alopecia Areata and Its Association With Anxiety and Depression: A Case-Control Study in Patients Referred to Dermatology Clinics

    January 2026 in “ International Journal of Clinical Practice ”
    Azar Shirzadian Kebria, Arash Abbaspour Firouzjah, Faezeh Khorshidian, Hemmatollah Gholinia Ahangar
    Studysummary This study found that individuals with alopecia areata have higher levels of anxiety and depression compared to healthy individuals, with longer disease duration linked to increased anxiety and severe severity predicting higher depression.
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    Research cited in this study 10

    1. Exploring the Overlap Between Alopecia Areata and Major Depressive Disorder: Epidemiological and Genetic Perspectives Journal of the European Academy of Dermatology and Venereology · 2023
    2. Assessing the Role of Stressful Life Events in the Induction and Recurrence of Alopecia Areata: A Case-Control Study Journal of the American Academy of Dermatology · 2022
    3. The Associated Burden of Mental Health Conditions in Alopecia Areata: A Population-Based Study in UK Primary Care British Journal of Dermatology · 2022
    4. Alopecia Areata Treatment Patterns, Healthcare Resource Utilization, and Comorbidities in the US Population Using Insurance Claims Advances in Therapy · 2021
    5. Patient Perspectives of the Social, Emotional and Functional Impact of Alopecia Areata: A Systematic Literature Review Dermatology and Therapy · 2021
    6. Assessment of a Bidirectional Association Between Major Depressive Disorder and Alopecia Areata JAMA Dermatology · 2019
    7. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    8. The Role of Micronutrients in Alopecia Areata: A Review American Journal of Clinical Dermatology · 2017
    9. Comorbidities in Patients with Alopecia Areata Journal of the American Academy of Dermatology · 2017
    10. Environmental Stress But Not Subjective Distress in Children or Adolescents With Alopecia Areata Journal of psychosomatic research · 2011