Evaluation of Quality of Life, Anxiety and Depression in Patients with Alopecia Areata: A Prospective Case-Control Study

September 2025 in “ Cyprus Journal of Medical Sciences ”

Pınar Özdemir Çetinkaya, Ömer Kutlu

This study evaluated the psychosocial impact of alopecia areata (AA) on patients by comparing 70 individuals with AA to 70 matched controls. The results showed that patients with AA had significantly higher anxiety and depression scores, as well as a greater impact on their quality of life, as measured by the hospital anxiety and depression scale (HADS) and the dermatology life quality index (DLQI). The findings highlight the importance for clinicians to identify and manage psychiatric comorbidities in patients with AA, even in the early stages of the condition.

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research Psychosocial and Mental Impact of Alopecia Areata: Analysis of the Danish Skin Cohort

17 citations , June 2024 in “Journal of the European Academy of Dermatology and Venereology”

The study on the Danish Skin Cohort highlights the significant psychosocial and mental impact of alopecia areata (AA), emphasizing the need for appropriate tools to measure quality of life. It identifies that factors such as the severity of AA, female sex, and eyebrow involvement can potentially heighten the psychosocial burden experienced by individuals with AA.

research Patient-Reported Burden of Severe Alopecia Areata: First Results from the Multinational Alopecia Areata Unmet Need Survey

March 2024 in “Clinical, cosmetic and investigational dermatology”

Severe alopecia areata greatly impacts quality of life, mental health, and daily activities.

research Classification of Psychodermatological Disorders: Proposal of a New International Classification

2 citations , December 2023 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

The document suggests a new way to categorize skin and mind disorders into two main groups to reduce confusion.

research Assessing the Role of Stressful Life Events in the Induction and Recurrence of Alopecia Areata: A Case-Control Study

7 citations , March 2022 in “Journal of the American Academy of Dermatology”

Stress can trigger or worsen alopecia areata.

Alopecia Areata Is Characterized by Dysregulation in Systemic Type 17 and Type 2 Cytokines, Which May Contribute to Disease-Associated Psychological Morbidity

research Alopecia Areata Is Characterized by Dysregulation in Systemic Type 17 and Type 2 Cytokines, Which May Contribute to Disease-Associated Psychological Morbidity

57 citations , April 2019 in “British journal of dermatology/British journal of dermatology, Supplement”

Alopecia areata involves immune system imbalances that may lead to depression and anxiety.

research Comorbidities in Alopecia Areata: A Systematic Review and Meta-Analysis

100 citations , July 2018 in “Journal of The American Academy of Dermatology”

People with alopecia areata often have other health issues like skin diseases, metabolic syndrome, stomach infections, lupus, anemia, thyroid problems, mental health issues, vitamin D deficiency, and hearing and eye problems.

research Alopecia Areata: Overview and Insights from January 2018

290 citations , December 2017 in “Journal of The American Academy of Dermatology”

Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

16 citations , April 2011 in “Recent Patents on Inflammation & Allergy Drug Discovery”

Alopecia Areata is an autoimmune disease causing hair loss in patches, often starting before age 20, and while some cases recover on their own, treatments include topical corticosteroids, minoxidil, and promising new methods like IL-31 antibodies and 308-nm Excimer laser therapy.