A Pharmacogenetic Survey of Androgen Receptor (CAG)N and (GGN)N Polymorphisms in Patients Experiencing Long Term Side Effects after Finasteride Discontinuation

    Erika Cecchin, Elena De Mattia, Giorgio Mazzon, Sabina Cauci, Carlo Trombetta, Giuseppe Toffoli
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    TLDR Longer CAG and GGN repeats increase alopecia risk, but no significant link to post-finasteride syndrome found.
    This study investigated the relationship between two genetic polymorphisms in the androgen receptor (AR) gene and the development of androgenetic alopecia (AGA) and post-finasteride syndrome (PFS). The study found that the longer CAG and GGN repeats were associated with a higher risk of AGA, and that the extreme values of both polymorphisms were associated with a reduced AR functionality. However, the study did not find a significant association between the two genetic polymorphisms and the occurrence of AGA or PFS. The study suggests that further prospective trials are needed to better investigate this phenomenon and to highlight possible pharmacogenetic predictive markers of toxicity development.
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