Increasing the Percutaneous Absorption and Follicular Penetration of Retinal by Topical Application of Proretinal Nanoparticles

March 2019 in “ European journal of pharmaceutics and biopharmaceutics ”

Benchaphorn Limcharoen, Pattrawadee Toprangkobsin, Wijit Banlunara, Supason Wanichwecharungruang, Heike Richter, Jürgen Lademann, Alexa Patzelt

retinal proretinal nanoparticles PRN chitosan stratum corneum hair follicles infundibular area retinoids topical retinoids retinol nanoparticles skin absorption hair follicle penetration

Studysummary This study observed that proretinal nanoparticles delivered significantly higher concentrations of retinal to the stratum corneum and hair follicles compared to non-particulate forms, potentially improving topical retinoid therapy.

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