Isotope Dilution-Based Targeted and Nontargeted Carbonyl Neurosteroid/Steroid Profiling

March 2018 in “ Analytical chemistry ”

Sheila Sharp, Stephen J. Mitchell, Monique Vallée, Elena Kuzmanova, Michelle A. Cooper, Delia Belelli, Jeremy J. Lambert, Jeffrey Huang

finasteride pregnenolone progesterone 3α,5α-tetrahydroprogesterone neurosteroids steroids isotope dilution hydroxylamine derivatization mass spectrometry MS/MS analysis Propecia

Studysummary This study found that a new analytical approach revealed an increased brain pregnenolone level following finasteride treatment in a mouse model, suggesting potential for improved understanding of neurosteroid roles in brain excitability.

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research Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients

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research Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

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research A High-Performance Liquid Chromatography–Tandem Mass Spectrometry Assay of the Androgenic Neurosteroid 3α-Androstanediol (5α-Androstane-3α,17β-Diol) in Plasma

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research Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA A Receptor Function and Seizure Susceptibility

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This study observed that acute stress in rats increased neurosteroid levels linked to enhanced GABA(A) receptor function, raising seizure thresholds, while similar effects were seen in mice with deoxycorticosterone administration.