The Role of Natural Hydrogels in Enhancing Wound Healing: From Biomaterials to Bioactive Therapies

    September 2025 in “ Pharmaceutics ”
    Paula Stefana Pintilei, Roya Binaymotlagh, Laura Chronopoulou, Cleofe Palocci
    Studysummary This review highlights the potential of natural hydrogels as advanced wound dressings, emphasizing their capabilities in mimicking the extracellular matrix, supporting healing, and delivering therapeutic agents for chronic and infected wound care.
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    Research cited in this study 11

    1. Strategies for Optimizing Acute Burn Wound Therapy: A Comprehensive Review Medicina · 2025
    2. Regenerative Cosmetics: Skin Tissue Engineering for Anti-Aging, Repair, and Hair Restoration 2024
    3. Dermal Fibrosis and the Current Scope of Hydrogel Strategies for Scarless Wound Healing Fibrosis · 2024
    4. Self-Assembled Peptide Hydrogels in Regenerative Medicine Gels · 2023
    5. Recent Advances in Biodegradable and Biocompatible Synthetic Polymers Used in Skin Wound Healing Materials · 2023
    6. Multifunctional Self-Assembled Peptide Hydrogels for Biomedical Applications Polymers · 2023
    7. Autophagy: Guardian of Skin Barrier Biomedicines · 2022
    8. Silk Gel Recruits Specific Cell Populations for Scarless Skin Regeneration Applied Materials Today · 2021
    9. The Dynamics of the Skin’s Immune System International Journal of Molecular Sciences · 2019
    10. Multidomain Peptide Hydrogel Accelerates Healing of Full-Thickness Wounds in Diabetic Mice ACS Biomaterials Science & Engineering · 2018
    11. Dextran Hydrogel Scaffolds Enhance Angiogenic Responses and Promote Complete Skin Regeneration During Burn Wound Healing Proceedings of the National Academy of Sciences · 2011