Epidermal Stem Cells Are Defined by Global Histone Modifications Altered by Myc-Induced Differentiation

August 2007 in “ PLoS ONE ”

Michaela Frye, Amanda G. Fisher, Fiona M. Watt

Studysummary This study found that Myc activation in epidermal stem cells leads to chromatin modifications that promote stem cell exit and differentiation, which can be influenced by HDAC inhibitors like trichostatin A.

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Research cited in this study

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research Heterogeneous Stem Cells in Skin Homeostasis and Wound Repair

58 citations , August 2015 in “The Indonesian Biomedical Journal”

This article reviews recent advancements in understanding the diverse populations of skin stem cells and their role in skin homeostasis, but it reports no new experimental findings.

research Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis

1279 citations , November 2005 in “Nature Medicine”

research Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis

421 citations , September 2003 in “Development”

This study concluded that label-retaining cells in mouse epidermis differ in their sensitivity to proliferative stimuli, influencing their division and potential transdifferentiation without consistently depleting their population.

research Evidence That Myc Activation Depletes the Epidermal Stem Cell Compartment by Modulating Adhesive Interactions with the Local Microenvironment

182 citations , May 2003 in “Development”

This study found that Myc activation in mouse epidermis impairs keratinocyte adhesion and motility by downregulating extracellular matrix and cytoskeleton proteins, affecting hair lineage differentiation.

research Deregulated Expression of c-Myc Depletes Epidermal Stem Cells

315 citations , June 2001 in “Nature Genetics”

research C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny

338 citations , April 2001 in “Current Biology”

This study found that transient activation of c-Myc in transgenic mice stimulates keratinocyte proliferation and sebocyte differentiation, affecting normal epidermal and hair follicle development.