Pooled, Frozen, Gamma-Irradiated Amniotic Fluid Enhances Histomorphological Remodeling in Hypertrophic Scars

    October 2025 in “ International Wound Journal ”
    Gamze Tümentemur, Elif Ganime Aygün, Bulut Yurtsever, Ercüment Ovalı
    Studysummary In a study using a rat model of hypertrophic scars, researchers found that gamma-irradiated human amniotic fluid improved wound healing, collagen remodelling, immune response, and scar characteristics more effectively than saline or non-irradiated amniotic fluid, indicating its potential for clinical applications in scar management.
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    Research cited in this study 4

    1. Effect of amniotic fluid on hair follicle growth Journal of Dermatological Treatment · 2025
    2. Recent Understandings of Biology, Prophylaxis, and Treatment Strategies for Hypertrophic Scars and Keloids International journal of molecular sciences · 2018
    3. Wound Healing and Skin Regeneration Cold Spring Harbor Perspectives in Medicine · 2015
    4. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007