Bioengineering a 3D Integumentary Organ System from iPS Cells Using an In Vivo Transplantation Model

April 2016 in “ Science Advances ”

Ryo Takagi, Junko Ishimaru, Ayaka Sugawara, Koh ei Toyoshima, Kentaro Ishida, Miho Ogawa, Kooko Sakakibara, Kyosuke Asakawa, Akitoshi Kashiwakura, Masamitsu Oshima, Ryohei Minamide, Akio Sato, Toshihiro Yoshitake, Akiko Takeda, Hiroshi Egusa, Takashi Tsuji

induced pluripotent stem cells iPS cells 3D integumentary organ system hair follicles sebaceous glands clustering-dependent embryoid body transplantation CDB transplantation hair eruption hair cycling stem cells niches in vitro assays organ replacement therapies hair growth hair cycle

Studysummary Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.

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