Bio-Pulsed Stimulation Effectively Improves the Production of Avian Mesenchymal Stem Cell-Derived Extracellular Vesicles That Enhance the Bioactivity of Skin Fibroblasts and Hair Follicle Cells

November 2022 in “ International journal of molecular sciences ”

Ju-Sheng Shieh, Yu-Tang Chin, Hsien‐Chung Chiu, Ya-Yu Hsieh, Hui-Rong Cheng, Hui Gu, Fong Ching Chang

Studysummary This study reported that bio-pulsed avian-derived mesenchymal stem cell extracellular vesicles significantly improved cell proliferation, wound healing, and gene expression in human skin fibroblasts and hair follicle cells.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study investigated the effects of bio-pulsed small extracellular vesicles (sEVs) derived from avian mesenchymal stem cells (AMSCs) on skin fibroblasts and hair follicle cells. The AMSCs were treated with Polygonum multiflorum Thunb extract, resulting in AMSC-sEVs that contained more exosomal proteins and RNAs than the control. These bio-pulsed AMSC-sEVs significantly enhanced cell proliferation, wound healing, collagen expression, and anti-inflammation in human skin fibroblasts (HSFs) and human follicle dermal papilla cells (HFDPCs). They also improved hair follicle activity by upregulating the expression of follicle activity-associated genes and cell proliferative genes, and decreasing the expression of apoptosis genes. The study suggests potential applications of bio-pulsed AMSC-sEVs in skin and hair regeneration therapies.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

Polygonum Multiflorum Extract Supports Hair Growth by Elongating Anagen Phase and Abrogating the Effect of Androgen in Cultured Human Dermal Papilla Cells

research Polygonum Multiflorum Extract Supports Hair Growth by Elongating Anagen Phase and Abrogating the Effect of Androgen in Cultured Human Dermal Papilla Cells

15 citations , May 2020 in “BMC complementary medicine and therapies”

This study found that Polygonum multiflorum extract may promote hair growth by increasing anagen duration and activating dermal papilla cells in human hair follicles, as observed in cultured cell models.

Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

research Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

58 citations , March 2019 in “Experimental Dermatology”

This study suggests that exosomes derived from dermal papilla cells, especially those cultured in three dimensions, promote hair growth and regeneration by enhancing follicular cell activity.

research Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-Conditioning

320 citations , December 2018 in “Frontiers in Immunology”

This review explores how preconditioning mesenchymal stromal cells can impact their secretome's therapeutic potential in regenerative medicine, emphasizing immunomodulatory and regenerative functions, but provides no new clinical results.

research Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine

773 citations , August 2017 in “International Journal of Molecular Sciences”

This article reviews the potential advantages of secretome derivatives from human uterine cervical stem cells in MSC therapy and notes the need for regulatory standards to ensure safety and efficacy.

research Overexpression of mIGF-1 in Keratinocytes Improves Wound Healing and Accelerates Hair Follicle Formation and Cycling in Mice

55 citations , October 2008 in “American Journal Of Pathology”

mIGF-1 in skin cells speeds up wound healing and hair growth in mice without harmful effects.