Fabrication of Thymoquinone and Ascorbic Acid-Loaded Spanlastics Gel for Hyperpigmentation: In Vitro Release, Cytotoxicity, and Skin Permeation Studies

    January 2025 in “ Pharmaceutics ”
    Ahlam Zaid Alkilani, Rua’a Alkhaldi, Haneen A. Basheer … Maram A. Alhusban
    Studysummary This study found that spanlastic gel loaded with thymoquinone and ascorbic acid improved skin deposition and tyrosinase inhibition, suggesting potential as a treatment for hyperpigmentation.
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    Research cited in this study 5

    1. Spanlastic-Laden Nanogel for Dermal Delivery of Bimatoprost in Androgenic Alopecia International journal of pharmaceutics. X · 2024
    2. Topical Drug Delivery Strategies for Enhancing Drug Effectiveness by Skin Barriers, Drug Delivery Systems, and Individualized Dosing Frontiers in Pharmacology · 2024
    3. Formulation Optimization, In Vitro and In Vivo Evaluation of Niosomal Nanocarriers for Enhanced Topical Delivery of Cetirizine Saudi Pharmaceutical Journal · 2023
    4. A Comprehensive Review on Skin Pigmentation: Types, Causes, and Treatment Preprints.org · 2023
    5. Melanocyte Chitosan/Gelatin Composite Fabrication with Human Outer Root Sheath-Derived Cells to Produce Pigment Scientific Reports · 2019