Local Synthesis and Function of Neuro-Estrogen and Neuro-Androgen: Impact on Hippocampus-Related Cognition and Neuronal Plasticity

This study found that boosting the synthesis of neural-derived 17β-estradiol effectively counteracted the impairment of hippocampal long-term potentiation caused by amyloid beta 1-42 in rat hippocampal slices, with the effect seemingly linked to glutamate NMDAR signaling.

This review discusses the local production and role of sex steroids in the hippocampal neurons of adult rodents and reports no new experimental findings.

This study describes molecular mechanisms explaining how sex and stress steroids rapidly modulate dendritic spine formation in hippocampal neurons, suggesting recovery-like effects under steroid-depleted conditions compared to intact conditions.

This study found that local synthesis of 17β-estradiol and 5α-dihydrotestosterone, combined with specific stimulation patterns, is crucial in determining the direction and strength of long-term synaptic effects in the hippocampal CA1 region of male rat slices.

This study found that in male rat hippocampal slices, DHT is necessary for low frequency stimulation-induced long-term depression, while E2 synthesis is essential for high frequency stimulation-induced long-term potentiation.

This study found that testosterone treatment in older hypogonadal men caused minor improvements in depressive symptoms and visuospatial memory, but overall, major cognitive benefits were not observed.