De Novo Follicular Regeneration of the Skin by Wingless Int 3 and Bone Morphogenetic Protein 2 Genes Introduced into Dermal Fibroblasts and Fibroblast Growth Factor-2 Protein

May 2009 in “ Wound Repair and Regeneration ”

Ichiro Ono, Yoshikiyo Akasaka, Takafumi Kamiya, Makito Sato, Masayoshi Kobune, Hirofumi Hamada, Toshiharu Yamashita

follicular regeneration wingless int 3 bone morphogenetic protein 2 dermal fibroblasts fibroblast growth factor-2 adenovirus vectors hair follicles pilosebaceous systems

Studysummary This study found that transplanting genetically modified dermal fibroblasts into full-thickness skin defects in rats led to the formation of hair follicles with mature pilosebaceous systems by 16 weeks.

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Research cited in this study

16 / 16 results

research Cutaneous Stem Cells: Something New and Something Borrowed

19 citations , October 2007 in “Wound Repair and Regeneration”

This paper reviews signaling influences and niches of epidermal stem cells and compares various types, but does not present new experimental findings.

research New Hair From Healing Wounds

57 citations , May 2007 in “Nature”

This study suggests that wounding skin in adult mice can trigger new hair follicle formation, indicating mammalian skin may have greater regenerative capacity than previously thought.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research The Potential of Nestin-Expressing Hair Follicle Stem Cells in Regenerative Medicine

50 citations , February 2007 in “Expert Opinion on Biological Therapy”

This study found that hair follicle stem cells can effectively enhance nerve regeneration and restore function in peripheral nerve injuries in mice, suggesting their potential as a source for autologous stem cell therapy.

research Scratching the Surface of Skin Development

788 citations , February 2007 in “Nature”

This review explores how adult skin epithelia preserve stem cell populations for hair follicle regeneration and wound healing, but reports no new experimental results.

research Bone Morphogenetic Protein Signaling Regulates the Size of Hair Follicles and Modulates the Expression of Cell Cycle-Associated Genes

92 citations , November 2006 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that transgenic mice overexpressing the BMP antagonist noggin showed increased hair follicle size and altered hair type, linked to changes in cell proliferation and gene expression.

research Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation

74 citations , September 2006 in “Cell Cycle”

This review examines the role of Hairless, a nuclear receptor corepressor, in regulating Wnt signaling during hair cycling and reports no new clinical results.

research Adult Bone-Marrow-Derived Mesenchymal Stem Cells Contribute to Wound Healing of Skin Appendages

201 citations , August 2006 in “Cell and Tissue Research”

research Wnt Signaling Induces Epithelial Differentiation During Cutaneous Wound Healing

159 citations , January 2006 in “BMC Cell Biology”

This study found that manipulating Wnt signaling pathways in cutaneous wounds can induce skin structures resembling regeneration, suggesting a potential role for Wnt signals in restoring skin architecture during wound healing.

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

550 citations , December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

This study found that bulge cells marked by CD200+ in human hair follicles show high colony-forming efficiency, suggesting successful enrichment of keratinocyte stem cells.

research BMP Signaling in the Control of Skin Development and Hair Follicle Growth

165 citations , December 2004 in “Differentiation”

This review discusses the critical role of BMP signaling in the development and regulation of skin and hair follicles and notes that further research could aid therapeutic advances; it presents no new clinical results.

research Shift of Localized Growth Zones Contributes to Skin Appendage Morphogenesis: Role of the Wnt/β-Catenin Pathway

75 citations , January 2003 in “Journal of Investigative Dermatology”

research Bone Morphogenetic Proteins and Their Antagonists in Skin and Hair Follicle Biology

176 citations , January 2003 in “Journal of Investigative Dermatology”

This review summarizes the roles of bone morphogenetic proteins in the development and regulation of normal and diseased skin, but it does not provide new clinical results.

research Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation

990 citations , October 1999 in “Development”

This study found that LEF1/TCF3 is necessary but not sufficient for TOPGAL activation in hair follicle development, indicating complex regulation in the skin.

research WNT Signaling in the Control of Hair Growth and Structure

271 citations , March 1999 in “Developmental biology”

This study reveals that overexpression of Wnt3 in transgenic mouse skin leads to a short-hair phenotype and cyclical balding due to structural defects in hair shafts, highlighting a role for WNT signaling in hair growth regulation.

research Expression of Morphogens During Human Follicle Development In Vivo and a Model for Studying Follicle Morphogenesis In Vitro

29 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

This article reviews the role of epithelial-mesenchymal interactions in hair follicle development and discusses the challenges of understanding the signals that regulate this complex process; it reports no new results.