Role of Neurosteroids in the Anticonvulsant Activity of Midazolam

    October 2011 in “ British Journal of Pharmacology
    Ashish Dhir, Michael A. Rogawski
    Studysummary This study found that enhanced neurosteroid synthesis likely mediated by the translocator protein contributed to the anticonvulsant action of midazolam in mice.
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    Research cited in this study 7

    1. 11β-Hydroxylase Inhibitors Protect Against Seizures in Mice by Increasing Endogenous Neurosteroid Synthesis Neuropharmacology · 2011
    2. Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning Through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis Journal of Neuroscience · 2010
    3. Involvement of Neurosteroids in the Anxiolytic-Like Effects of AC-5216 in Mice Pharmacology Biochemistry and Behavior · 2008
    4. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    5. A New Look at the 5α-Reductase Inhibitor Finasteride 2006
    6. Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA A Receptor Function and Seizure Susceptibility Journal of Neuroscience · 2002
    7. Finasteride, a 5alpha-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice PubMed · 1999