Pharmacologic Modulation of Sebaceous Gland Activity: Mechanisms and Clinical Applications

    April 2007 in “ Dermatologic Clinics ”
    Shari Clarke, Amanda M. Nelson, Rosalyn George, Diane Thiboutot
    Studysummary This review discusses the mechanisms by which isotretinoin and hormonal therapy treat acne through their effects on sebaceous glands, reporting no new clinical results.
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    Research cited in this study 11

    1. Antiandrogen Therapy for Skin and Hair Disease Dermatologic Clinics · 2006
    2. Acne The New England Journal of Medicine · 2005
    3. Sex Steroid Hormone Receptors in Human Skin Appendages and Their Neoplasms Endocrine Journal · 2005
    4. Hirsutism and Acne in Polycystic Ovary Syndrome Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology · 2004
    5. The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit Journal of Investigative Dermatology Symposium Proceedings · 2003
    6. Update and Future of Hormonal Therapy in Acne Dermatology · 2003
    7. Endocrinological Evaluation and Hormonal Therapy for Women with Difficult Acne Journal of The European Academy of Dermatology and Venereology · 2001
    8. Acneiform Dermatoses Dermatology · 1998
    9. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
    10. Clinical Efficacy and Safety of Low-Dose Flutamide Alone and Combined with an Oral Contraceptive for the Treatment of Idiopathic Hirsutism Clinical endocrinology · 1995
    11. Androgens Affect the Activity of Human Sebocytes in Culture Depending on the Localization of the Sebaceous Glands, and Their Effect Is Antagonized by Spironolactone Skin Pharmacology and Physiology · 1994

    Related research 1

    1. Pharmacologic Modulation of Sebaceous Gland Activity: Mechanisms and Clinical Applications Dermatologic Clinics · 2007