Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin

    March 2017 in “ Cell host & microbe ”
    Tiffany C. Scharschmidt, Kimberly S. Vasquez, Mariela Pauli … Michael D. Rosenblum
    Studysummary The researchers reported that hair follicle development and commensal microbe colonization promote the accumulation of regulatory T cells in neonatal skin, with the Ccl20-Ccr6 pathway playing a key role in this process.
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    Research cited in this study 8

    1. Skin CD4+ Memory T Cells Exhibit Combined Cluster-Mediated Retention and Equilibration with the Circulation Nature communications · 2016
    2. Hair Follicle-Derived IL-7 and IL-15 Mediate Skin-Resident Memory T Cell Homeostasis and Lymphoma Nature medicine · 2015
    3. Mechanisms Regulating Skin Immunity and Inflammation Nature Reviews Immunology · 2014
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    5. Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin Nature Immunology · 2012
    6. Pattern of Tissue Invasion by Propionibacterium Acnes in Acne Vulgaris Journal of dermatological science · 2012
    7. Canonical WNT Signaling Promotes Mammary Placode Development and Is Essential for Initiation of Mammary Gland Morphogenesis Development · 2004
    8. Hair Follicle Embryogenesis in Humans: Characterization of Events In Vivo and In Vitro PubMed · 1991