Effects of Mitotane Treatment on Human Steroid Metabolism: Implications for Patient Management

    July 2012 in “ Endocrine Connections
    Lea Ghataore, Indrani Chakraborti, Simon Aylwin … Nicholas F. Taylor
    Studysummary This study found that mitotane causes specific changes in cortisol metabolism, including increased excretion of certain metabolites, which may influence cortisol bioavailability without hindering early detection of adrenocortical carcinoma recurrence.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on ec.bioscientifica.com →
    Discuss this study in the Community →

    Research cited in this study 3

    1. Effects of Mitotane Treatment on Human Steroid Metabolism: Implications for Patient Management Endocrine Connections · 2012
    2. Inhibition of Human Steroid 5β-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex Journal of Biological Chemistry · 2009
    3. C19 and C21 5β/5α Metabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency The Journal of Clinical Endocrinology and Metabolism · 1990