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Glossary Mitotane

Mitotane is a medication primarily used in the treatment of adrenocortical carcinoma, a rare type of cancer affecting the adrenal glands. Its relevance to hair loss lies in its potential side effects, which can include alopecia or thinning hair due to its impact on adrenal hormone production. Mitotane works by inhibiting steroidogenesis, leading to decreased levels of cortisol and other adrenal hormones, which can disrupt normal hair growth cycles. Key distinguishing characteristics of mitotane include its specific use in cancer therapy and its mechanism of action that targets adrenal function rather than directly affecting hair follicles.

Research

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research Adrenal steroid hormone concentrations in dogs with hair cycle arrest (Alopecia X) before and during treatment with melatonin and mitotane

52 citations , October 2004 in “Veterinary dermatology”

This study found that 62% of neutered dogs with hair cycle arrest experienced partial to complete hair re-growth after melatonin treatment, but hair re-growth was not consistently linked to normal sex hormone levels.

research Effects of mitotane treatment on human steroid metabolism: implications for patient management

26 citations , July 2012 in “Endocrine Connections”

This study found that mitotane causes specific changes in cortisol metabolism, including increased excretion of certain metabolites, which may influence cortisol bioavailability without hindering early detection of adrenocortical carcinoma recurrence.

research Growth hormone-responsive alopecia in dogs

21 citations , May 2005 in “Journal of the American Veterinary Medical Association”

The exact cause of growth hormone-responsive alopecia in dogs is unclear.

research Androgen- and Estrogen-Secreting Adrenal Cancers

14 citations , December 2010 in “Seminars in Oncology”

This review discusses the diagnostic challenges of androgen and estrogen-secreting adrenal tumors and highlights that the presence of metastases is the most reliable indicator of malignancy; it reports no new clinical findings.

research Tertiary hypothyroidism in a dog

14 citations , February 2007 in “Irish Veterinary Journal”

This study reported the first known case of tertiary hypothyroidism in a dog, diagnosed after a Labrador treated for hyperadrenocorticism presented with related symptoms and an MRI-revealed pituitary mass.

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