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    Glossary Mitotane

    Mitotane is a medication primarily used in the treatment of adrenocortical carcinoma, a rare type of cancer affecting the adrenal glands. Its relevance to hair loss lies in its potential side effects, which can include alopecia or thinning hair due to its impact on adrenal hormone production. Mitotane works by inhibiting steroidogenesis, leading to decreased levels of cortisol and other adrenal hormones, which can disrupt normal hair growth cycles. Key distinguishing characteristics of mitotane include its specific use in cancer therapy and its mechanism of action that targets adrenal function rather than directly affecting hair follicles.

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    1. Adrenal steroid hormone concentrations in dogs with hair cycle arrest (Alopecia X) before and during treatment with melatonin and mitotane Veterinary dermatology · 2004 · 52 citations
    2. Effects of mitotane treatment on human steroid metabolism: implications for patient management Endocrine Connections · 2012 · 26 citations
    3. Growth hormone-responsive alopecia in dogs Journal of the American Veterinary Medical Association · 2005 · 21 citations
    4. Androgen- and Estrogen-Secreting Adrenal Cancers Seminars in Oncology · 2010 · 14 citations
    5. Tertiary hypothyroidism in a dog Irish Veterinary Journal · 2007 · 14 citations
    6. Concurrent hyperadrenocorticism in a minature schnauzer with severe <i>Trichophyton mentagrophytes</i> infection Veterinary Dermatology · 2002 · 5 citations
    7. Modern Approaches to Treatment of Alopecia X in Dogs: Review of Research Russian Journal of Veterinary Pathology · 2023
    8. ODP021 A Feminizing Adrenocortical Carcinoma Presenting with Marie-Antoinette Syndrome Journal of the Endocrine Society · 2022
    9. MON-323 Metastatic Adrenocortical Carcinoma Presenting with Mixed Cushing's and Virilization Syndrome along with Bilateral Pulmonary Emboli Journal of the Endocrine Society · 2019
    10. Pituitary-dependent hyperadrenocorticism in a terrier dog: A case report Journal of Coastal Life Medicine · 2016
    11. Diagnosis and Treatment of the Cushing Syndrome in Dogs Journal of the Japan Veterinary Medical Association · 1983
    12. A Case of Renin-Producing Adrenocortical Cancer. Endocrine Journal · 2000 · 14 citations
    13. Case Report: Pulsed electric field treatment of metastatic liver disease demonstrating a possible abscopal response Frontiers in Immunology · 2026
    14. Case Report: Pulsed electric field treatment of metastatic liver disease demonstrating a possible abscopal response UNC Libraries · 2026
    15. Case Report: Pulsed electric field treatment of metastatic liver disease demonstrating a possible abscopal response UNC Libraries · 2026
    16. Microneedling as a successful treatment for alopecia X in two Pomeranian siblings Veterinary Dermatology · 2015 · 12 citations
    17. Toward a Diagnostic Score in Cushing's Syndrome Frontiers in Endocrinology · 2019 · 42 citations
    18. Oestrogen receptor evaluation in Pomeranian dogs with hair cycle arrest (alopecia X) on melatonin supplementation Veterinary dermatology · 2006 · 20 citations
    19. Symmetrical alopecia in the dog In Practice · 1999 · 7 citations
    20. Hyperadrenocorticism in Ferrets 2013 · 6 citations
    21. Deslorelin treatment of hyperoestrogenism in neutered ferrets (Mustela putorius furo): a case report Veterinární Medicína · 2009 · 6 citations
    22. Influence of sex and functional status on the value of serum steroid profiling in discriminating adrenocortical carcinoma from adrenocortical adenoma Frontiers in Endocrinology · 2024 · 4 citations
    23. A small scale study to evaluate the efficacy of microneedling in the presence or absence of platelet‐rich plasma in the treatment of post‐clipping alopecia in dogs Veterinary Dermatology · 2019 · 2 citations
    24. Aromatase inhibitor–induced hair loss in two adolescents Pediatric Dermatology · 2020 · 1 citations
    25. Adrenal causes of endocrine hypertension in childhood or adolescence Journal of Endocrinological Investigation · 2025
    26. A Very Rare Reason for Hyperandrogenism: Adrenal Tumor Case Bagcılar medical bulletin · 2023
    27. Étude des contaminants transportés par les microplastiques dans le milieu marin Libanais theses.fr (ABES) · 2022
    28. Les hormones sexuelles et la peau : questionnaire à l'attention des vétérinaires praticiens. Mise à jour bibliographique et synthèse HAL (Le Centre pour la Communication Scientifique Directe) · 2014
    29. Index 2013
    30. Canine alopecia X Companion Animal · 2009