Inhibition of 5α-Reductase in the Nucleus Accumbens Counters Sensorimotor Gating Deficits Induced by Dopaminergic Activation

    October 2011 in “ Psychoneuroendocrinology ”
    Paola Devoto, Roberto Frau, Valentina Bini … Marco Bortolato
    Studysummary Finasteride may help improve certain brain function issues linked to dopamine.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 9

    1. Finasteride Attenuates Pathological Gambling in Patients With Parkinson's Disease Journal of Clinical Psychopharmacology · 2012
    2. A Preliminary Study of Finasteride in Tourette Syndrome Movement Disorders · 2011
    3. Isolation Rearing-Induced Reduction of Brain 5α-Reductase Expression: Relevance to Dopaminergic Impairments Neuropharmacology · 2011
    4. Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders Current Pharmaceutical Design · 2011
    5. Improvement of General Symptoms in a Chronic Psychotic Patient Treated with Finasteride: Case Report Pharmacopsychiatry · 2008
    6. Antipsychotic-Like Properties of 5-Alpha-Reductase Inhibitors Neuropsychopharmacology · 2008
    7. Treatment of Tourette’s Syndrome With Finasteride American Journal of Psychiatry · 2007
    8. Progesterone Enhances Ethanol-Induced Modulation of Mesocortical Dopamine Neurons: Antagonism by Finasteride Journal of Neurochemistry · 2002
    9. Four-Amino Acid Segment in Steroid 5 Alpha-Reductase 1 Confers Sensitivity to Finasteride, a Competitive Inhibitor Journal of Biological Chemistry · 1992