Patterns of Epithelial Expression of Fos Protein Suggest Important Role in the Transition from Viable to Cornified Cell During Keratinization

February 1991 in “ Development ”

Chris Fisher, Margaret R. Byers, Michael J. Iadarola, Elaine A. Powers

Fos protein c-fos epithelial cells keratinization cornification epidermis hair follicle cells Erf Er mutant

Studysummary This study found that Fos protein expression is closely linked to epithelial cell differentiation, particularly during cornification and cell death, with overexpression observed in keratinization-blocked mutant epidermis.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

View this study on journals.biologists.com →

Discuss this study in the Community →

Related Research

8 / 8 results

research Damage of Hair Follicle Stem Cells and Alteration of Keratin Expression in External Radiation-Induced Acute Alopecia

28 citations , June 2012 in “International Journal of Molecular Medicine”

This study observed that while X-ray radiation did not alter major hair keratin composition in mice, it decreased hair follicle stem cell markers and increased Krt5, suggesting potential as a radiation biomarker.

research Using High-Throughput Immunoblotting to Identify Proteins Involved in the Differentiation of Embryonic Stem Cells Along the Hair Follicle Lineage In Vitro

4 citations , April 2011 in “Stem Cell Reviews and Reports”

This research describes a two-step culture system for pluripotent mouse ES cells that produces hair follicle-like structures, providing a valuable model to study stem cell differentiation in vitro.

research Modulation of the Differentiated Phenotype of Keratinocytes of the Hair Follicle and Epidermis

41 citations , July 1994 in “Journal of Dermatological Science”

This review examines the differentiation potential of epithelial cells from various sources in hair follicle formation, concluding that complex interactions are required for hair-specific characteristics, which were achieved in vivo but not in vitro.

research Patterns of Epithelial Expression of Fos Protein Suggest Important Role in the Transition from Viable to Cornified Cell During Keratinization

83 citations , February 1991 in “Development”

This study found that Fos protein expression is closely linked to epithelial cell differentiation, particularly during cornification and cell death, with overexpression observed in keratinization-blocked mutant epidermis.

research Architecture of Reconstructed Epidermis on Collagen Lattices Varies According to the Method Used: A Comparative Study

9 citations , January 1990 in “Skin Pharmacology and Physiology”

This study observed that 67 kDa keratin was expressed homogeneously only in epidermis derived from hair follicle explants, differing from other culture methods where expression was delayed and patchy.

research Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation

198 citations , November 1989 in “The Journal of Cell Biology”

This study reported that K14 expression patterns and keratin filament organization in human skin's hair follicles differ from those in the epidermis, indicating distinct differentiation programs.

research A New Look Into an Old Problem: Keratins as Tools to Investigate Determination, Morphogenesis, and Differentiation in Skin

156 citations , January 1989 in “Genes & Development”

This study found that keratin K14 expression occurs early in epidermal cell differentiation, while a hair-specific keratin is expressed later in hair matrix cells, suggesting developmental divergence between the two cell types.

research Different Keratin Polypeptides in Epidermis and Other Epithelia of Human Skin: A Specific Cytokeratin of Molecular Weight 46,000 in Epithelia of the Pilosebaceous Tract and Basal Cell Epitheliomas

277 citations , October 1982 in “The Journal of Cell Biology”

This study found that the cytokeratin patterns in skin epithelia can distinguish between different types, with basal-cell epitheliomas showing a striking similarity to the pilosebaceous tract.