Hair Follicle Stem Cell Replication Stress Drives IFI16/STING-Dependent Inflammation in Hidradenitis Suppurativa

April 2020 in “ Journal of Clinical Investigation ”

Cindy Orvain, Yea-Lih Lin, Francette Jean-Louis, Hakim Hocini, Barbara Hersant, Yamina Bennasser, Nicolas Ortonne, C. Hotz, Pierre Wolkenstein, Michele Boniotto, Pascaline Tisserand, Cécile Lefebvre, Jean‐Daniel Lelièvre, Monsef Benkirane, Philippe Pasero, Yves Lévy, Sophie Hüe

hair follicle stem cells hidradenitis suppurativa replication stress progenitor cells quiescent stem cells replication fork progression ATR/CHK1 pathway cytosolic single-stranded DNA outer root sheath cells DNA damage response cytoplasmic ssDNA micronuclei interferon synthesis IFI16/STING pathway HFSCs HS ssDNA ORSCs

Studysummary This study found that hair follicle stem cells from hidradenitis suppurativa patients showed alterations in cell cycle regulation and DNA replication, potentially linking genetic predisposition to the skin inflammation characteristic of the disease.

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