Two Mechanisms Regulate Keratin K15 Expression in Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signaling

    June 2012 in “ PloS one ”
    Amrita Bose, Muy-Teck Teh, Iain Hutchison … Ahmad Waseem
    Studysummary This study suggests that Keratin 15 expression in stratified epithelia may be regulated by two distinct mechanisms involving PKC/AP-1 pathway for differentiation and FOXM1 for basal cells, challenging its reliability as a sole stem cell marker.
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    Research cited in this study 12

    1. Reassessing K15 as an Epidermal Stem Cell Marker Stem Cell Reviews and Reports · 2011
    2. Cytokeratin 15 Expression in Central, Centrifugal, Cicatricial Alopecia: New Observations in Normal and Diseased Hair Follicles Journal of Cutaneous Pathology · 2011
    3. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    4. Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and After Transplantation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    5. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    6. Location and Phenotype of Human Adult Keratinocyte Stem Cells of the Skin Differentiation · 2004
    7. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    8. Genes for Intermediate Filament Proteins and the Draft Sequence of the Human Genome Journal of Cell Science · 2001
    9. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    10. Cytokeratin 15 Expression in Trichoepitheliomas and a Subset of Basal Cell Carcinomas Suggests They Originate from Hair Follicle Stem Cells Journal of Cutaneous Pathology · 1999
    11. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999
    12. Expression of the Intermediate Filament Keratin Gene K15 in the Basal Cell Layers of Epithelia and the Hair Follicle Experimental Cell Research · 1998