The Effects of Spermidine on Functional and Transcriptomic Markers in Human Primary Keratinocytes

October 2025 in “ Physiologia ”

Derick A. Anglin, Madison L. Mattingly, Nicholas J. Kontos, Michael D. Roberts

spermidine keratinocytes HR gene hair follicle pan-keratin mitochondrial membrane potential

Studysummary In this exploratory in vitro study, treatment with spermidine increased cell viability and altered gene expression in human epidermal keratinocytes, suggesting potential benefits to cellular health and function, though effects on mitochondrial markers were not significant.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

research Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche

74 citations , October 2023 in “Nature Reviews Molecular Cell Biology”

research The Expanding Significance of Keratin Intermediate Filaments in Normal and Diseased Epithelia

186 citations , December 2012 in “Current opinion in cell biology”

This review discusses the recent advancements in understanding how keratins influence cytoarchitecture, cell dynamics, and disease processes but reports no new clinical results; the authors highlight its roles in development and diseases like cancer.

research Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions

61 citations , July 2011 in “PLOS ONE”

This study provides the first direct evidence that spermidine can stimulate hair growth and modulate human epithelial stem cell biology in cultured human hair follicles.

research Molecular and Functional Aspects of the Hairless (Hr) Gene in Laboratory Rodents and Humans

126 citations , October 1998 in “Experimental Dermatology”

This review provides an overview of the hairless gene in mice and humans, discussing its structure, expression, and implications for understanding skin physiology and human disorders related to gene disruption, but it reports no new empirical findings.

research Inhibition of Polyamine Synthesis Alters Hair Follicle Function and Fiber Composition

42 citations , February 1996 in “Journal of Investigative Dermatology”

This study found that spermidine, a polyamine, plays an essential role in hair growth in sheep follicles, while spermine is not required for normal follicle function.