28 citations
,
September 2013 in “European Journal of Histochemistry”
This study demonstrates a varied distribution of keratins in the epidermis of the Malayan pangolin, suggesting evolutionary adaptations related to their distinctive scales.
In this exploratory in vitro study, treatment with spermidine increased cell viability and altered gene expression in human epidermal keratinocytes, suggesting potential benefits to cellular health and function, though effects on mitochondrial markers were not significant.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”
This study found that Imaging Mass Cytometry effectively visualizes multiple biomarkers in alopecia areata, enhancing analysis of immune cell and tissue interactions in hair pathology.
In this study, water-soluble recombinant keratins, specifically RK81, were developed and used in microneedles to investigate their effect on hair growth, discovering that more than 40% of the hair follicles responded, demonstrating the potential for hair growth promotion.
186 citations
,
December 2012 in “Current opinion in cell biology”
This review discusses the recent advancements in understanding how keratins influence cytoarchitecture, cell dynamics, and disease processes but reports no new clinical results; the authors highlight its roles in development and diseases like cancer.
The user has been experiencing aggressive hair loss despite using finasteride, minoxidil, dutasteride, ketoconazole, and derma rolling. Suggestions include continuing current treatments, considering RU58841, checking for deficiencies, and possibly trying collagen supplements or oral minoxidil.