Preparation and Optimization of Garlic Oil/Apple Cider Vinegar Nanoemulsion Loaded with Minoxidil to Treat Alopecia

    December 2021 in “ Pharmaceutics ”
    Waleed Y. Rizg, Khaled M. Hosny, Samar S Elgebaly … Rasha A Khallaf
    Studysummary This study developed a nanoemulsion of garlic oil and apple cider vinegar loaded with minoxidil to enhance drug permeation through skin, reporting improved ex vivo skin permeation parameters compared to an aqueous dispersion of minoxidil, suggesting potential benefits for treating alopecia areata.
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    Research cited in this study 9

    1. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    2. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    3. Is Propionibacterium Acnes Associated With Hair Casts And Alopecia? International Journal of Trichology · 2012
    4. Solid Lipid Nanoparticles Suspension Versus Commercial Solutions for Dermal Delivery of Minoxidil International Journal of Pharmaceutics · 2011
    5. Penetration Enhancer-Containing Vesicles as Carriers for Cutaneous Delivery of Minoxidil International Journal of Pharmaceutics · 2009
    6. Combination of Topical Garlic Gel and Betamethasone Valerate Cream in the Treatment of Localized Alopecia Areata: A Double-Blind Randomized Controlled Study Indian Journal of Dermatology Venereology and Leprology · 2007
    7. Evidence-Based Treatment of Alopecia Areata Journal of the American Academy of Dermatology · 2001
    8. Comparison of Alopecia Areata in Human and Nonhuman Mammalian Species Pathobiology · 1998
    9. Cutaneous Immunopathology of Androgenetic Alopecia The Journal of the American Osteopathic Association · 1991

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    3. Niosomes as a Vesicular Carrier for Topical Administration of Minoxidil: Formulation and In Vitro Assessment Drug Delivery and Translational Research · 2013
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