The CD44+ALDH+ Population of Human Keratinocytes Is Enriched for Epidermal Stem Cells with Long-Term Repopulating Ability
January 2013
in “
Stem cells
”
epidermal stem cells EpiSCs human neonatal keratinocytes HNKs aldehyde dehydrogenase ALDH CD44 integrin α6 CD71 nuclear Bmi-1 holoclones multipotent hair follicle-like structures label retention colony formation keratinocyte growth media embryonic stem cell growth media stem cells keratinocytes integrin alpha-6 Bmi-1 hair follicles keratinocyte media embryonic stem cell media
Studysummary This study found that the CD44(+) ALDH(+) population of neonatal human keratinocytes exhibited enhanced stem cell properties, including significantly increased long-term epidermal regeneration and multipotency, compared to unfractionated cells.
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