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    Transcriptome Analysis of Skin from SMP30/GNL Knockout Mice Reveals the Effect of Ascorbic Acid Deficiency on Skin and Hair

    June 2017 in “ in Vivo ”
    Koji Wakame, Kenichi Komatsu, Akifumi Nakata … Hiroo Uchiyama
    Studysummary This study found that vitamin C deficiency in SMP-30/GNL-KO mice affected gene expression related to hair growth and cell growth, resulting in delayed hair growth compared to those with adequate vitamin C.
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    Research cited in this study 5

    1. Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production Through Sonic Hedgehog Genes & Development · 2016
    2. Wnt Signaling in Skin Development, Homeostasis, and Disease Cold Spring Harbor Perspectives in Biology · 2012
    3. Hairy Tale of Signaling in Hair Follicle Development and Cycling Seminars in cell & developmental biology · 2012
    4. Induction of Versican by Ascorbic Acid 2-Phosphate in Dermal Papilla Cells Journal of Dermatological Science · 2006
    5. The Hair Growth Promoting Effect of Ascorbic Acid 2-Phosphate, a Long-Acting Vitamin C Derivative Journal of Dermatological Science · 2006