Transplanted Hair Follicle Stem Cells Migrate to the Penumbra and Express Neural Markers in a Rat Model of Cerebral Ischemia/Reperfusion

September 2020 in “ Stem Cell Research & Therapy ”

Xuemei Zhang, Hao Tang, Senlin Mao, Bing Li, Yinglian Zhou, Hui Yue, Duo Wang, Yifei Wang, Jin Fu

hair follicle stem cells HFSCs stem cells pluripotency

Studysummary Hair follicle stem cells may help repair the brain after a stroke.

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Research cited in this study

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research VEGF165 Induces Differentiation of Hair Follicle Stem Cells Into Endothelial Cells and Plays a Role in In Vivo Angiogenesis

36 citations , February 2017 in “Journal of Cellular and Molecular Medicine”

In this study, VEGF165 induced hair follicle stem cells to differentiate into vascular endothelial cells, potentially supporting angiogenesis and neovascularization, with the Notch signaling pathway affecting differentiation efficiency.

research Neuroendocrinology of the Hair Follicle: Principles and Clinical Perspectives

98 citations , July 2014 in “Trends in Molecular Medicine”

This article discusses the role of human hair follicles in neuroendocrinology and suggests potential new therapeutic targets by examining how neuromediators influence hair growth, pigmentation, and stem cell biology in organ cultures.

research Uncomplicated Differentiation of Stem Cells Into Bipolar Neurons and Myelinating Glia

33 citations , September 2008 in “Biochemical and Biophysical Research Communications”

Hair follicles can be used to easily create neurons and glial cells for potential nerve repair.

research Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles

344 citations , June 2006 in “American Journal Of Pathology”

Human hair follicles can provide stem cells for regenerative medicine.

research Implanted Hair Follicle Stem Cells Form Schwann Cells That Support Repair of Severed Peripheral Nerves

319 citations , November 2005 in “Proceedings of the National Academy of Sciences”

This study suggests that hair follicle stem cells from transgenic mice can improve nerve regeneration and function, highlighting their potential as an autologous source for regenerative medicine.

research Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons

419 citations , March 2005 in “Proceedings of the National Academy of Sciences”

This study demonstrated that ND-GFP stem cells from the hair-follicle bulge area can differentiate into various cell types, including neurons, suggesting their potential as a source for therapeutic applications.

research Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells

212 citations , August 2004 in “Proceedings of the National Academy of Sciences”

This study found that nestin-driven GFP labels blood vessels originating from hair follicles in mice, which could be used to study early events in skin angiogenesis and for antiangiogenesis drug screening.

Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

research Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

130 citations , January 1994 in “Differentiation”

In this study, researchers found that bulge cells in mouse hair follicles undergo transient proliferation during early anagen, indicating their role as follicular stem cells. However, another factor beyond dermal papilla proximity may be required to initiate a new anagen phase.