Transplanted Hair Follicle Stem Cells Migrate to the Penumbra and Express Neural Markers in a Rat Model of Cerebral Ischemia/Reperfusion

    May 2020 in “ Research Square (Research Square) ”
    Xuemei Zhang, Hao Tang, Senlin Mao … Jin Fu

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that hair follicle stem cells, when transplanted in a rat model of ischaemic stroke, migrated to affected areas, expressed neuron-specific markers, and reduced infarct volume, suggesting potential therapeutic benefits.
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    Research cited in this study 6

    1. Uncomplicated Differentiation of Stem Cells Into Bipolar Neurons and Myelinating Glia Biochemical and Biophysical Research Communications · 2008
    2. Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles American Journal Of Pathology · 2006
    3. Implanted Hair Follicle Stem Cells Form Schwann Cells That Support Repair of Severed Peripheral Nerves Proceedings of the National Academy of Sciences · 2005
    4. Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons Proceedings of the National Academy of Sciences · 2005
    5. Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells Proceedings of the National Academy of Sciences · 2004
    6. Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles Differentiation · 1994