Transplanted Hair Follicle Stem Cells Migrate to the Penumbra and Express Neural Markers in a Rat Model of Cerebral Ischemia/Reperfusion

May 2020 in “ Research Square (Research Square) ”

Xuemei Zhang, Hao Tang, Senlin Mao, Bing Li, Yinglian Zhou, Hui Yue, Duo Wang, Yifei Wang, Jin Fu

Studysummary This study found that hair follicle stem cells, when transplanted in a rat model of ischaemic stroke, migrated to affected areas, expressed neuron-specific markers, and reduced infarct volume, suggesting potential therapeutic benefits.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study investigated the potential of hair follicle stem cells (HFSCs) in treating ischaemic stroke using a rat model. Researchers administered HFSCs intravenously and found that these cells migrated to the penumbra, expressed neuron-specific markers, reduced infarct volume, and promoted neurological recovery. The findings suggested that HFSC transplantation could have therapeutic potential for ischaemic stroke, indicating a promising avenue for future clinical development.

View this study on researchsquare.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research Uncomplicated Differentiation of Stem Cells Into Bipolar Neurons and Myelinating Glia

33 citations , September 2008 in “Biochemical and Biophysical Research Communications”

Hair follicles can be used to easily create neurons and glial cells for potential nerve repair.

research Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles

344 citations , June 2006 in “American Journal Of Pathology”

Human hair follicles can provide stem cells for regenerative medicine.

research Implanted Hair Follicle Stem Cells Form Schwann Cells That Support Repair of Severed Peripheral Nerves

319 citations , November 2005 in “Proceedings of the National Academy of Sciences”

This study suggests that hair follicle stem cells from transgenic mice can improve nerve regeneration and function, highlighting their potential as an autologous source for regenerative medicine.

research Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons

419 citations , March 2005 in “Proceedings of the National Academy of Sciences”

This study demonstrated that ND-GFP stem cells from the hair-follicle bulge area can differentiate into various cell types, including neurons, suggesting their potential as a source for therapeutic applications.

research Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells

212 citations , August 2004 in “Proceedings of the National Academy of Sciences”

This study found that nestin-driven GFP labels blood vessels originating from hair follicles in mice, which could be used to study early events in skin angiogenesis and for antiangiogenesis drug screening.

Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

research Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

130 citations , January 1994 in “Differentiation”

In this study, researchers found that bulge cells in mouse hair follicles undergo transient proliferation during early anagen, indicating their role as follicular stem cells. However, another factor beyond dermal papilla proximity may be required to initiate a new anagen phase.