Evidence-Based and Potential Benefits of Metformin in Polycystic Ovary Syndrome: A Comprehensive Review

    December 2008 in “ Endocrine Reviews ”
    Stefano Palomba, Angela Falbo, Fulvio Zullo, Francesco Orio
    Studysummary This review discusses the various evidence-based and potential applications of metformin in treating and preventing symptoms and complications associated with polycystic ovary syndrome but reports no new clinical results.
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    Research cited in this study 18

    1. Impact of Metformin and Rosiglitazone Treatment on Glucose Transporter 4 mRNA Expression in Women with Polycystic Ovary Syndrome European journal of endocrinology · 2008
    2. Insulin Sensitizers for the Treatment of Hirsutism: A Systematic Review and Meta-Analyses of Randomized Controlled Trials The Journal of Clinical Endocrinology & Metabolism · 2008
    3. Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline The Journal of Clinical Endocrinology & Metabolism · 2008
    4. Mood and Sexual Function in Polycystic Ovary Syndrome Seminars in reproductive medicine · 2008
    5. A Systematic Review of Commonly Used Medical Treatments for Hirsutism in Women Clinical endocrinology · 2007
    6. Metformin Improves Polycystic Ovary Syndrome Symptoms Irrespective of Pre-Treatment Insulin Resistance European journal of endocrinology · 2007
    7. Relationship Between Androgen Levels and Blood Pressure in Young Women With Polycystic Ovary Syndrome Hypertension · 2007
    8. Dermatologic Manifestations of Polycystic Ovary Syndrome American Journal of Clinical Dermatology · 2007
    9. Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline The Journal of Clinical Endocrinology and Metabolism · 2006
    10. Metformin Treatment of Polycystic Ovary Syndrome Improves Health-Related Quality of Life, Emotional Distress, and Sexuality Human reproduction · 2006
    11. Acute Alopecia Due to Metformin Treatment for Polycystic Ovarian Syndrome Journal of obstetrics and gynaecology · 2006
    12. Infertility in Polycystic Ovary Syndrome: Focus on Low-Dose Gonadotropin Treatment Endocrine journal · 2006
    13. Health-Related Quality of Life in Women with Polycystic Ovary Syndrome: A Comparison with the General Population Using the Polycystic Ovary Syndrome Questionnaire and the Short Form-36 Gynecological Endocrinology · 2006
    14. Androgen Excess in Women: Experience with Over 1000 Consecutive Patients The Journal of Clinical Endocrinology and Metabolism · 2004
    15. Metformin or Antiandrogen in the Treatment of Hirsutism in Polycystic Ovary Syndrome ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2003
    16. The Effect of Metformin on Hirsutism in Polycystic Ovary Syndrome European journal of endocrinology · 2002
    17. Gender Differences in the Regulation of Blood Pressure Hypertension · 2001
    18. Pilosebaceous Physiology in Relation to Hirsutism and Acne Clinics in endocrinology and metabolism · 1986