Skinspan: A Holistic Roadmap for Extending Skin Longevity With Evidence-Based Interventions

    September 2025 in “ Journal of Cosmetic Dermatology ”
    Elizabeth Kream, Sabrina G. Fabi, Monica Boen
    Studysummary This study introduces the "skinspan" framework to promote skin longevity through sun protection, topical retinoids, and antioxidants as first-line care. It suggests lasers and emerging therapies as additional options but emphasizes the need for more randomized controlled trials to solidify the evidence base.
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    Research cited in this study 6

    1. Exosomes in Dermatology: A Comprehensive Review of Current Applications, Clinical Evidence, and Future Directions International Journal of Dermatology · 2025
    2. Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo International Journal of Molecular Sciences · 2023
    3. Melatonin and the Human Hair Follicle Journal of Drugs in Dermatology · 2023
    4. Protective Role of Melatonin and Its Metabolites in Skin Aging International Journal of Molecular Sciences · 2022
    5. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    6. Brain And Muscle Arnt-Like Protein-1 (BMAL1) Controls Circadian Cell Proliferation And Susceptibility To UVB-Induced DNA Damage In The Epidermis Proceedings of the National Academy of Sciences of the United States of America · 2012