Endogenous Skin Fluorescence Is a Good Marker for Objective Evaluation of Comedolysis
Studysummary This study found that fluorescence excitation spectroscopy could be a promising noninvasive tool for assessing the effects of comedolytic agents like retinoids on acne-like lesions in rhino mice. Our plain-language summary of this paper — not a Tressless recommendation.
The study concluded that endogenous skin fluorescence was an effective marker for objectively evaluating comedolysis. Using 36 female rhino mice treated with varying concentrations of all-trans retinoic acid (tRA), researchers observed significant changes in fluorescence spectra that correlated with histologic changes in the skin, such as utriculi size and dermal/epidermal thickness. Higher tRA concentrations led to more pronounced fluorescence changes, indicating effective comedolysis. This noninvasive method could potentially replace invasive histology for assessing comedolytic agents.
