The Intervention Effect of Externally Applying or Orally Administering Bifidobacterium Animalis Subsp. Lactis J12 on Atopic Dermatitis Induced by 2,4-Dinitrofluorobenzene
January 2026
in “
Microorganisms
”
Bifidobacterium animalis subsp. lactis J12 atopic dermatitis 2,4-dinitrofluorobenzene gut microbiota systemic immune regulation topical application oral administration inflammatory cytokines regulatory T cells Bifidobacterium lactis J12 AD gut bacteria immune system topical treatment oral treatment inflammation T cells
Studysummary In a DNFB-induced mouse model of atopic dermatitis, this study found that both topical and oral formulations of the probiotic <i>Bifidobacterium animalis</i> J12 improved AD symptoms through distinct mechanisms, with topical applications reducing local inflammation and oral administration enhancing gut microbiota and reducing systemic inflammation.
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