Adipocytic Progenitor Cells Give Rise to Pathogenic Myofibroblasts: Adipocyte-to-Mesenchymal Transition and Its Emerging Role in Fibrosis in Multiple Organs

    September 2020 in “ Current Rheumatology Reports ”
    Roberta Gonçalves Marangoni, Benjamin D. Korman, John Varga
    Studysummary This review discusses the emerging role of AMT in fibrosis and suggests that targeting AMT could offer a novel approach to treatment; it reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on link.springer.com →
    Discuss this study in the Community →

    Research cited in this study 11

    1. Dissecting Fibroblast Heterogeneity in Health and Fibrotic Disease Current Rheumatology Reports · 2020
    2. Dermal Adipose Tissue Has High Plasticity And Undergoes Reversible Dedifferentiation In Mice Journal of Clinical Investigation · 2019
    3. Dermal White Adipose Tissue: A Newly Recognized Layer of Skin Innate Defense Journal of Investigative Dermatology · 2019
    4. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018
    5. Fibroblast Heterogeneity: Implications for Human Disease Journal of Clinical Investigation · 2018
    6. Adipocyte-Myofibroblast Transition as a Possible Pathophysiological Step in Androgenetic Alopecia Experimental Dermatology · 2017
    7. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    8. Defining Dermal Adipose Tissue Experimental Dermatology · 2014
    9. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    10. Intradermal Adipocytes Mediate Fibroblast Recruitment During Skin Wound Healing Development · 2013
    11. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011