Guiding Skin Organoid Generation via Extracellular Matrix Cues and Spatially Controlled Morphogen Gradients
induced pluripotent stem cells iPSCs embryoid bodies EBs extracellular matrix ECM collagen type I laminin fibronectin skin organoids hair follicle generation 3D-bioprinted hydrogel microfluidic device differentiation factors skin cell lineages skin appendages pigmentation stem cells collagen skin cells hair follicles 3D printing microfluidics
Studysummary This study found that carefully engineered hydrogels and asymmetric morphogen gradients facilitated the formation of anatomically relevant skin organoids from iPSC-derived EBs, improving pigmentation and hair follicle generation.
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