Opinions & Experiences with topical Spironolactone? Treatment 1/24/2022
Hair loss discussion includes topical Spironolactone's effectiveness and minimal side effects. Community members share personal experiences and opinions on its use.
View this post in the Community →
Similar Community Posts Join
5 / 1000+ resultscommunity Topical spironolactone question
User started using topical spironolactone on scalp and face, experienced fever feeling and sluggishness. Asks if side effects are normal or systemic.
community Regrowth on hairline doesn’t get longer no matter what treatment I try
Finding treatments for regrowth on the hairline which have not been successful so far, with suggestions of maintaining what they currently have and considering a hair transplant as an option.
community 5 months on Spiro and 6 weeks on oral Monoxidil. Beyond thrilled with the results so far
Treatments for hair loss, specifically the use of Spironolactone (Spiro) and oral Minoxidil, as well as Finasteride and RU58841.
community Combining spironolactone with koshine?
Combining spironolactone with koshine might enhance the effect of blocking androgen receptors for hair loss treatment. The user suggests adding crushed spironolactone pills to koshine.
community HRT is literal black magic. Fin 1 mg/day @ 4 years, min 2x/day @ 3 years, Estradiol 4mg/day @ 3.5 months, and Spironolactone 100mg/day @ 3.5 months (estra & spiro are medicines you should likely not take if you are a cis man)
User shared progress on hair regrowth using Fin 1 mg/day for 4 years, Min 2x/day for 3 years, Estradiol 4mg/day, and Spironolactone 100mg/day for 3.5 months. They noted significant hairline recovery and advised against HRT for cis men due to feminizing effects.
Related Research
6 / 1000+ resultsresearch Dermoscopic Evaluation of the Efficacy of Combination of Topical Spironolactone 5% and Minoxidil 5% Solutions in the Treatment of Androgenetic Alopecia: A Cross-Sectional Comparative Study
Using both 5% spironolactone and 5% minoxidil together is safe and more effective for treating hair loss.
![Topical Spironolactone in the Treatment of Ocular Graft-Versus-Host Disease](/images/research/836dd978-abc5-42f7-ab9f-fe242a2fb8ed/small/36761.jpg)
research Topical Spironolactone in the Treatment of Ocular Graft-Versus-Host Disease
Topical spironolactone may help treat ocular graft-versus-host disease with minimal side effects.
![Medical Management Options for Hair Loss](/images/research/a3e13dec-68a3-4b9b-93a7-ab8ba9468537/small/14755.jpg)
research Medical Management Options for Hair Loss
The document concluded that FDA-approved treatments like minoxidil and finasteride are effective for hair loss, while the effectiveness of natural remedies and other non-approved treatments is not well-supported by evidence.
![Regulation of Hair Growth](/images/research/30e792c7-eaf0-40ef-9ed5-9c0e1d9e1275/small/34422.jpg)
research Regulation of Hair Growth
The document concludes that treatments like oral anti-androgens, minoxidil, and topical spironolactone can be effective for hair loss in men and women.
![RU 58841, A New Specific Topical Antiandrogen: A Candidate of Choice for the Treatment of Acne, Androgenetic Alopecia, and Hirsutism](/images/research/22c72f57-74fc-4f8d-b13d-4cb48dc748c4/small/2025.jpg)
research RU 58841, A New Specific Topical Antiandrogen: A Candidate of Choice for the Treatment of Acne, Androgenetic Alopecia, and Hirsutism
RU 58841 may treat acne, hair loss, and excessive hair growth.
![Polymeric Micelle Mediated Follicular Delivery of Spironolactone: Targeting the Mineralocorticoid Receptor to Prevent Glucocorticoid-Induced Activation and Delayed Cutaneous Wound Healing](/images/research/f8bae941-45a2-4684-8aff-176148925211/small/20790.jpg)
research Polymeric Micelle Mediated Follicular Delivery of Spironolactone: Targeting the Mineralocorticoid Receptor to Prevent Glucocorticoid-Induced Activation and Delayed Cutaneous Wound Healing
Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.