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Glossary Vitamin D Receptor

protein that binds vitamin D to regulate gene expression

The Vitamin D Receptor (VDR) is a protein found in various cells throughout the body that binds to vitamin D, allowing it to regulate the expression of specific genes. This receptor plays a crucial role in maintaining calcium and phosphate balance, which is essential for healthy bone formation, and it also influences immune system function and hair follicle cycling.

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Research

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research Lentinula edodes (Shiitake) extract as a vitamin D receptor activator to enhance skin adaptogenic responses

August 2026 in “Scientific Reports”

This study suggests that a Lentinula edodes extract can improve skin barrier function, hydration, and sebum regulation, possibly by modulating vitamin D pathways, in individuals with oily and acne-prone skin.

research Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer

28 citations , January 2012 in “Biological & pharmaceutical bulletin”

This study found that the protein hairless acts as both a corepressor and coactivator of the vitamin D receptor, influencing gene transcription in a ligand-selective manner.

research Vitamin D activates type A natriuretic peptide receptor gene transcription in inner medullary collecting duct cells

17 citations , April 2007 in “Kidney international”

This study found that 1,25 dihydroxyvitamin D3 significantly increased the expression and activity of vasculoprotective natriuretic peptide receptor-A in cultured inner medullary collecting duct cells, suggesting a potential mechanistic role in cardiovascular and renal benefits.

research The Vitamin D Receptor Is Required for Activation of cWnt and Hedgehog Signaling in Keratinocytes

56 citations , September 2014 in “Molecular Endocrinology”

This study found that the absence of unliganded vitamin D receptor significantly impairs cWnt and hedgehog signaling pathways necessary for hair cycle initiation in VDR-null mice.

Stress-Induced c-Jun-Dependent Vitamin D Receptor Activation Dissects the Non-Classical VDR Pathway from the Classical VDR Activity

research Stress-induced c-Jun-dependent Vitamin D Receptor (VDR) Activation Dissects the Non-classical VDR Pathway from the Classical VDR Activity

31 citations , January 2007 in “Journal of biological chemistry/The Journal of biological chemistry”

This study found that c-Jun is essential for vitamin D receptor expression, and the vitamin D receptor inhibits c-Jun-dependent cell death through non-classical mechanisms independent of vitamin D3.

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Community Join

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community Sunlight: Does it Stimulate Hair Growth or Hair Loss?

in Research/Science 64 upvotes 2 years ago

The conversation discusses whether sunlight exposure affects hair growth or loss, with mixed anecdotes and theories but no clear consensus. Some suggest moderate sunlight can benefit hair by providing vitamin D, while others doubt its effectiveness compared to treatments like Minoxidil or finasteride.

community Supplements for Health hair as for Gemini & Grok

1 upvotes 9 months ago

The conversation discusses various supplements and vitamins like Vitamin D3, K2, Biotin, Iron, Zinc, and B Vitamins for improving hair health. It also mentions a combination of Tocotrienols, Pycnogenol, Saw Palmetto, Pumpkin Seed Oil, Stinging Nettle, and Myricetin for stabilizing hair, with Saw Palmetto, Pygeum, and Stinging Nettle noted for thickening hair despite side effects.

community How is it possible for someone to be a non responder to ORAL minoxidil?

in Minoxidil 66 upvotes 2 years ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

community progress has been insane, been having a bad shed for about a month or 2, can anyone explain?

in Progress Pictures 678 upvotes 2 years ago

User experienced significant hair regrowth using minoxidil and dutasteride, along with microneedling, vitamins, and massages. Despite recent shedding, they hope it's a synchronized hair cycle and plan to continue the treatment.

community Everyone, reply with your stacks and rate your results from 1-10

30 upvotes 2 months ago

Users shared their hair loss treatment routines, including finasteride, minoxidil, ketoconazole, and various supplements, with results ranging from 1/10 to 10/10. Some users reported stabilization and regrowth, while others noted minimal improvement or side effects.

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Learn

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learn Overview

learn Vitamin D

vitamin you should probably be taking for general health might also help your hair a little

What is the connection between Vitamin D and hair loss? Vitamin D deficiency may contribute to hair loss by disrupting hair follicle regulation.
Can Vitamin D deficiency trigger excessive hair shedding? Yes, vitamin D deficiency can trigger excessive hair shedding.
Is it safe to take Vitamin D supplements for hair growth? Vitamin D supplements are generally safe but may not significantly improve hair growth.
All 5 questions on Vitamin D →

learn Dexpanthenol

precursor of vitamin B5 with hair stimulating effects

learn Calcium D oantothenate

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Clinics

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Hair Loss Treatments
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