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research Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata

2 citations , December 2022 in “PNAS nexus”

In laboratory experiments, this study found that the topical prodrug SCD-153, a derivative of 4-methyl itaconate, reduced inflammation-related gene expression and induced significant hair growth in mice, suggesting it as a promising treatment candidate for alopecia areata.

research Hair coat characteristics in Friesian heifers in the Netherlands and Kenya : experimental data and a review of literature

12 citations , January 1978

The study observed that Friesian heifers experienced significant adaptation challenges to Kenya's equatorial conditions, taking around 18 months for their coat composition to resemble that of Dutch heifers in summer.

research Nanoemulgel for Efficient Topical Delivery of Finasteride Against Androgenic Alopecia

6 citations , August 2020 in “Journal of Pharmaceutical Innovation”

This study found that a lipid nanoemulsion-based gel of finasteride for topical use improved hair growth and was effective against alopecia, with slow skin permeation and increased efficacy compared to a testosterone-treated group.

research Topical Delivery of Tofacitinib in Dermatology: The Promise of a Novel Therapeutic Class Using Biodegradable Dendritic Polyglycerol Sulfates

1 citations , January 2024 in “Pharmaceuticals”

The researchers reported that dPGS-PCL as a carrier improved the penetration of tofacitinib in an ex-vivo human skin model compared to free tofacitinib, but did not show significant differences in inhibiting IL-6 and IL-8 during short incubation.

Development and Evaluation of Finasteride-Loaded Ethosomes for Targeting the Pilosebaceous Unit

research Development and evaluation of finasteride loaded ethosomes for targeting to the pilosebaceous unit

7 citations , October 2017 in “Artificial Cells Nanomedicine and Biotechnology”

This research observed that finasteride-loaded ethosomes showed improved permeation across rat skin and human cadaver scalp skin compared to unencapsulated finasteride, potentially enhancing delivery to hair follicle units.

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Community Join

5 / 134 results

community Attention Finasteride / Dutasteride and Your liver

374 upvotes 1 year ago

Finasteride may cause elevated liver enzymes, potentially leading to liver issues, though this is rare. Users should monitor liver function and consider topical alternatives if liver sensitivity occurs.

community DHT Itch and Oily Scalp Explained (and how to fix it)

90 upvotes 3 months ago

Malassezia overgrowth can worsen oily scalp and inflammation, contributing to hair loss. Treatments include antifungal shampoos, C6/C8 MCT oil, low-dose isotretinoin, finasteride, and dutasteride.

community Prevention when you have minimal hair loss

in Research/Science 13 upvotes 1 year ago

Starting finasteride, dutasteride, and minoxidil early is advised for minimal hair loss to preserve hair. Professional consultation is important due to potential side effects.

community this community is so funny bro

in Satire 1804 upvotes 1 year ago

Hair loss treatments like finasteride, minoxidil, and dutasteride are discussed, with users sharing mixed experiences about effectiveness and side effects. Some users report positive results, while others express concerns about side effects, highlighting the importance of personal choice.

community DHT results after 1 year on dutasteride, confused and seeking guidance

in Finasteride/Dutasteride 107 upvotes 1 year ago

The user is experiencing rapid hair loss despite using dutasteride, finasteride, and minoxidil, and is concerned about high estradiol and testosterone levels. They are advised to consult an endocrinologist for potential hormonal imbalances.

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Learn

6 / 801 results

learn Fluridil

a topical anti-androgen with less systemic involvement

learn Finasteride

Are there really risks with topical finasteride? Reports on topical finasteride describe scalp irritation and dermatitis as the effects specific to it, and blood levels lower than the oral drug; whether systemic side effects are genuinely rarer has not been measured in a trial powered to answer it. Both forms are prescription-only and contraindicated around pregnancy.
Topical or oral? Choosing between pills and lotions according to your case. Topical finasteride offers localized treatment with fewer systemic side effects than oral finasteride.
Is Finasteride unbeatable or are there equally powerful alternatives? Trials report finasteride as the single medication with the strongest measured effect in male androgenetic alopecia, while dutasteride, minoxidil, topical finasteride, PRP, LLLT and microneedling all have supporting studies and are often reported to work better in combination. Finasteride, dutasteride and oral minoxidil are prescription-only, and several of these uses are off-label.

learn RU58841

a potent but unapproved and potentially problematic topical anti-androgen

learn Bicalutamide

Is topical bicalutamide a safer alternative to finasteride? There is no published human trial of topical bicalutamide for hair loss, and no licensed topical product exists, so it cannot be called safer than finasteride — or shown to work at all. Oral finasteride has decades of trial data with a documented side-effect profile, and topical finasteride has a phase III trial behind it.

learn Fluocinolone

What precautions should I take when using Fluocinolone alongside other hair treatments? No verifiable controlled trial tests topical fluocinolone together with minoxidil, ketoconazole shampoo or scalp oils; clinics commonly advise spacing the products apart and clearing any new combination with the prescriber, because a corticosteroid-thinned scalp barrier is more easily irritated.

learn Latanoprost

glaucoma medication with hair follicle stimulant effects

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