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GlossaryTumor Necrosis Factor Alpha

protein involved in inflammation and immune system regulation

Tumor Necrosis Factor Alpha (TNF-α) is a protein produced by the immune system that plays a crucial role in inflammation and the body's response to infection. It helps regulate immune cells, but excessive production of TNF-α is associated with chronic inflammatory diseases like rheumatoid arthritis and psoriasis.

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Severe Infliximab-Induced Alopecia and Scalp Psoriasis in a Woman with Crohn’s Disease: Dramatic Improvement After Drug Discontinuation and Treatment with Adjuvant Systemic and Topical Therapies

research Severe Infliximab-Induced Alopecia and Scalp Psoriasis in a Woman with Crohn’s Disease: Dramatic Improvement After Drug Discontinuation and Treatment with Adjuvant Systemic and Topical Therapies

19 citations, November 2016 in “Dermatology and therapy”

Stopping the medication infliximab and starting new treatments helped a woman's hair grow back and improved her scalp condition.

research Treatment of Crohn's Disease and Concomitant Alopecia Areata With Tofacitinib

2 citations, November 2021 in “ACG Case Reports Journal”

Tofacitinib successfully treated hair loss in a Crohn's disease patient who previously used adalimumab.

Alopecia Induced by Tumor Necrosis Factor-Alpha Antagonists: Description of 52 Cases and Disproportionality Analysis in a Nationwide Pharmacovigilance Database

research Alopecia Induced by Tumor Necrosis Factor-Alpha Antagonists: Description of 52 Cases and Disproportionality Analysis in a Nationwide Pharmacovigilance Database

26 citations, March 2014 in “Rheumatology”

Some drugs used to treat inflammation may cause hair loss.

research Tumor Necrosis Factor-Alpha Inhibitor Associated Psoriasiform Alopecia

1 citations, April 2012 in “Informa Healthcare eBooks”

Some medications for inflammation can cause a condition with scalp rashes and hair loss, often linked to Crohn's disease, and may require treatment changes to prevent permanent hair loss.

research Hair Loss Induced by Tumor Necrosis Factor Alpha Inhibitors

2 citations, January 2014 in “Journal of clinical and investigative dermatology”

Some drugs used to treat immune conditions may cause different types of hair loss.

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community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 5 months ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community Pyrilutamide 5 months results (before, after pics)

in Progress Pictures 193 upvotes 1 year ago

Tae147 has shared results of using pyrilutamide, a 5% concentration topical solution applied twice daily, in combination with minoxidil, to reduce scalp itchiness and hair shedding. Other users have shared their experiences with the treatment, as well as questions about its availability on the market.

community Did anybody not care at all about their hair until they started losing it?

in Chat 134 upvotes 1 month ago

People regret neglecting their hair until it started thinning, and they are now using treatments like finasteride, minoxidil, and microneedling. Some are considering stronger options like dutasteride due to mixed results.

community ‘Long term use of fin/dut may be associated with health risks including fatty liver disease, insulin resistance, type 2 diabetes, dry eye disease and potential kidney disease.’

in Research/Science 22 upvotes 4 months ago

Long-term use of finasteride and dutasteride may be linked to health risks like fatty liver disease, insulin resistance, type 2 diabetes, dry eye disease, and potential kidney disease. Some users believe the risks are low and the medications are generally safe.

community How soon is hair clone? Next five years?!

in Research/Science 15 upvotes 4 months ago

Hair cloning is humorously discussed as always being 5-7 years away, with skepticism about its near-term availability. Gene editing to reactivate dormant follicles is suggested as a more likely solution within the next ten years.

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